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A novel meroterpenoid cabagranin D was isolated with related neolignans cabagranins A–C from the leaves ofPiper cabagranum(Costa Rica). Cabagranins A–C represent the first examples of 3,3′-neolignans isolated from the plant genusPiper, and the meroterpenoid cabagranin D displays an unprecedented Diels–Alder conjugate of an unsubstituted phenylpropenone and α-phellandrene. Details of the full structural elucidation of these compounds and a discussion of their potential biosynthetic relationships are presented. 

Synchronization primitives like barriers heavily impact the performance of parallel programs. As core counts increase and granularity decreases, the value of enabling fast barriers increases. Through the evaluation of the performance of a variety of software implementations of barriers, we found the cost of software barriers to be on the order of tens of thousands of cycles on various incarnations of x64 hardware. We argue that reducing the latency of a barrier via hardware support will dramatically improve the performance of existing applications and runtimes, and would enable new execution models, including those which currently do not perform well on multicore machines. To support our argument, we first present the design, implementation, and evaluation of a barrier on the Intel HARP, a prototype that integrates an x64 processor and FPGA in the same package. This effort gives insight into the potential speed and compactness of hardware barriers, and suggests useful improvements to the HARP platform. Next, we turn to the processor itself and describe an x64 ISA extension for barriers, and how it could be implemented in the microarchitecture with minimal collateral changes. This design allows for barriers to be securely managed jointly between the OS and the application. Finally, we speculate on how barrier synchronization might be implemented on future photonics-based hardware. 

Anthropogenic climate change is expected to affect global river flow. Here, we analyze time series of low, mean, and high river flows from 7250 observatories around the world covering the years 1971 to 2010. We identify spatially complex trend patterns, where some regions are drying and others are wetting consistently across low, mean, and high flows. Trends computed from state-of-the-art model simulations are consistent with the observations only if radiative forcing that accounts for anthropogenic climate change is considered. Simulated effects of water and land management do not suffice to reproduce the observed trend pattern. Thus, the analysis provides clear evidence for the role of externally forced climate change as a causal driver of recent trends in mean and extreme river flow at the global scale.